Control of White-Opaque Phenotypic Switching in Candida albicans by the Efg1p Morphogenetic Regulator
نویسندگان
چکیده
منابع مشابه
Chlamydospore formation in Candida albicans requires the Efg1p morphogenetic regulator.
Chlamydospore formation of the fungal pathogen Candida albicans was found to depend on the Efg1 protein, which regulates the yeast-hyphal transition. Isogenic mutants lacking EFG1 or encoding T206A and T206E variants did not differentiate chlamydospores, while cek1, cph1, or tpk2 mutations had no effect. Furthermore, filamentation of efg1 cph1 double mutants in microaerophilic conditions sugges...
متن کاملWhite-opaque switching in Candida albicans.
The human commensal yeast Candida albicans undergoes an epigenetic switch between two distinct types of cells, referred to as white and opaque. These two cell types differ in many respects, including their cell and colony morphologies, their metabolic states, their mating behaviors, their preferred niches in the host, and their interactions with the host immune system. Each of the two cell type...
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Candida albicans strains that are homozygous at the mating type locus (MTLa or MTLalpha) can spontaneously switch at a low frequency from the normal yeast cell morphology (white) to an elongated cell type (opaque), which is the mating-competent form of the fungus. The ability to switch reversibly between these two cell types also contributes to the pathogenicity of C. albicans, as white and opa...
متن کاملTOS9 regulates white-opaque switching in Candida albicans.
In Candida albicans, the a1-alpha2 complex represses white-opaque switching, as well as mating. Based upon the assumption that the a1-alpha2 corepressor complex binds to the gene that regulates white-opaque switching, a chromatinimmunoprecipitation-microarray analysis strategy was used to identify 52 genes that bound to the complex. One of these genes, TOS9, exhibited an expression pattern cons...
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To mate, Candida albicans must undergo homozygosis at the mating type-like locus MTL[1, 2], then switch from the white to opaque phenotype [3, 4]. Paradoxically, when opaque cells are transferred in vitro to 37 degrees C, the temperature of their animal host, they switch en masse to white [5-7], suggesting that their major niche might not be conducive to mating. It has been suggested that phero...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1999
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.67.9.4655-4660.1999